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Clinicals & Papers

  Heart Rate Variability (HRV)

      HRV Overview

      HRV & Cardiovascular Disease

      HRV & Diabetes

  Pulse Wave & Plethysmography

  Publications

Heart Rate Variability (HRV)

In 1994, a Task Force was established by the Board of the European Society of Cardiology and co-sponsored by the North American Society of Pacing and Electrophysiology to study Heart Rate Variability. In order to achieve their goals, the members of the Task Force were drawn from the fields of clinical medicine, physiology, mathematics, and engineering.

According to the Task Force, “The last two decades have witnessed the recognition of a significant relationship between the autonomic nervous system and cardiovascular mortality, including sudden cardiac death…an association between a propensity for lethal arrhythmias and signs of either increased sympathetic or reduced vagal activity has encouraged the development of quantitative markers of autonomic activity…Heart rate variability (HRV) represents one of the most promising such markers.”1

The Task Force established the following guidelines which are used by the Max Pulse screening device. Heart Rate Variability, European Heart Journal (1996) 17, 354-3811, Learn More…

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In 2003 in Seoul, Korea a study was done using the Max Pulse technology and involved 8 medical and research universities. According to the study, “With HRV’s usefulness as an evaluation tool of autonomic nerves, it is widely used on stress research…because stress reaction appears as biochemical physiological response in a human body through the response between HPA axis and autonomic nerves. The failure or abnormality of autonomic nerves is related to many of stress symptoms.”2 The study involved 3,483 patients and established a base line for measuring stress and how it correlates with HRV.
Learn More…
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1. Application of heart rate variability in prognosis of patients with diabetes mellitus.
Markuszewski L, Bissinger A. Pol Merkuriusz Lek. 2005 Oct;19(112):548-52. Read abstract...

2. A Measurement of Electrocardiography and Photoplethesmography in Obese Children.
C. V. Russoniello, V. Pougtachev, E. Zhirnov and M. T. Mahar.
Applied Psychophysiology and Biofeedback: Volume 35, Issue 3 (2010), Pages 257-259. Read abstract...

3. Guidelines for the management of arterial hypertension: the Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC).
Mancia G, De Backer G, Dominiczak A, et al. 2007. J Hypertens. 2007;25:1105-1187. Read abstract…

4. Noninvasive pulse wave analysis for the early detection of vascular disease.
Cohn J, Finkelstein S, McVeigh G, et al. Hypertension. 1995;26:503-508. Read abstract…

5. Contour analysis of the photoplethysmographic pulse measured at the finger.
Millasseau SC, Ritter JM, Takazawa K, Chowienczyk PJ. J Hypertens. 2006;24:1449-1456. Read abstract…

6. Pulse pressure and aortic pulse wave velocity are markers of cardiovascular risk in hypertensive populations.
Asmar R, Rudnichi A, Blacher J, London GM, Safar ME. Am J Hypertens. 2001;14:91-97. Read abstract…

7. Better management of cardiovascular diseases by pulse wave velocity: combining clinical practice with clinical research using evidence-based medicine.
Khoshdel AR, Carney SL, Nair BR, Gillies A. Clin Med Res. 2007;5:45-52. Read abstract…

8. Wave reflection in the systemic circulation and its implications in ventricular function.
O'Rourke MF, Kelly RP. J Hypertens. 1993;11:327-337. Read abstract…

9. Pulse wave analysis and arterial stiffness.
Wilkinson IB, Cockcroft JR, Webb DJ. J Cardiovasc Pharmacol. 1998;32:S33-S37. Read abstract…

10. Pulse wave velocity and the second derivative of the finger photoplethysmogram in treated hypertensive patients: their relationship and associating factors.
Hashimoto J, Chonan K, Aoki Y, et al. J Hypertens. 2002;20:2415-2422. Read abstract…

11. The peripheral pulse wave: information overlooked.
Murray WB, Foster PA. J Clin Monit. 1996;12:365-377. Read abstract…

12. Photoelectric plethysmography - some fundamental aspects of the reflection and transmission method.
Nijboer JA, Dorlas JC, Mahieu HF. Clin Phys Physiol Meas. 1981;2:205-215. Read abstract…

13. Frequency analysis of the peripheral pulse wave detected in the finger with the photoplethysmograph.
Sherebrin MH, Sherebrin RZ. IEEE Trans Biomed Eng. 1990;37:313-317. Read abstract…

14. Arterial stiffness: clinical relevance, measurement and treatment.
Izzo JL Jr, Shykoff BE. Rev Cardiovasc Med. 2001; 2:29-34,37-40. Read abstract…

15. Determination of age-related increases in large artery stiffness by digital pulse contour analysis.
Millasseau SC, Kelly RP, Ritter JM, Chowienczyk PJ. Clin Sci (Lond). 2002;103:371-377. Read abstract…

16. Waveform analysis of peripheral pulse wave detected in the fingertip with photoplethysmograph.
Hlimonenko I, Meigas K, Vahisalu R. Measure Sci Rev. 2003;3:49-52. Read abstract…

17. Photo-electric plethysmography as a monitoring device in anaesthesia.
Dorlas JC, Nijboer JA. Br J Anaesth. 1985;57:524-530. Read abstract…

18. An analysis of the relationship between central aortic and peripheral upper limb pressure waves in man.
Karamanoglu M, O'Rourke MF, Avolio AP, Kelly RP. Eur Heart J. 1993;14:160-167. Read abstract…

19. A photoelectric plethysmograph for the measurement of cutaneous blood flow.
Challoner AV, Ramsay CA. Phys Med Biol. 1974;19:317-328. Read abstract…

20. Annual progression of coronary calcification in trials of preventative therapies: a systematic review.
McCullough PA, Chinnaiyan KM. Arch Intern Med. 2009;169:2064-2070. Read abstract…

21. Repeatability of peripheral pulse measurements on ears, fingers and toes using photoelectric plethysmography.
Jago JR, Murray A. Clin Phys Physiol Measure. 1988;9:319-329. Read abstract…

22. Noninvasive determination of age related changes in the human arterial pulse.
Kelly RP, Hayward C, Avolio A, O'Rourke M. Circulation. 1989;80:1652-1659. Read abstract…

23. Aortic pulse wave velocity as a marker of cardiovascular risk in hypertensive patients.
Blacher J, Asmar R, Djane S, London GM, Safar ME. Hypertension. 1999;33:1111-1117. Read abstract…

24. Impact of aortic stiffness on survival in end-stage renal disease.
Blacher J, Guerin AP, Pannier B, Marchais SJ, Safar ME, London GM. Circulation. 1999;99:2434-2439. Read abstract…

25. A double take on serial measurement of coronary artery calcification.
O'Malley P. Arch Intern Med. 2009;169:2051-2052. Read abstract…

26. Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients.
Laurent S, Boutouyrie P, Asmar R, et al. Hypertension. 2001;37:1236-1241. Read abstract…

27. Studies of the arterial pulse wave and its modification in the presence of human arteriosclerosis.
Lax H, Feinberg AW, Cohen BM. J Chronic Dis. 1956;3:618-631. Read abstract…



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